New Cholesterol Drug Lowers Risk of Heart Attack and Stroke
Mar 21, 2017, 00:47
Peter Bach, for instance, director of the Center for Health Policy and Outcomes at Memorial Sloan-Kettering, emphasized that the number of CV events prevented would be too small for payers to save much money.
"As a practicing cardiologist who sees a lot of patients with severe dyslipidemia and/or statin intolerance, I am very excited by these data because I need all the tools I can get to reduce CVD risk, especially for patients with severe dyslipidemia or who can't tolerate statins, " Stein wrote in an email.
One major barrier is its high cost - it has a USA list price of $14,000 a year per patient.
The patients in the trial were already taking statins, and their risk was cut further by the new therapy.
"Investors have grown more cautious on the PCSK9 space following the less-than-stellar Fourier data from Amgen", said the analysts in a research note. Rind also was not involved in the study. In clinical trials, both Repatha and its competitor, a drug called Praluent developed by Sanofi and Regeneron, reduced LDL cholesterol by about 60% in patients already taking statins. "However, for lower risk patients this study still leaves payers with significant ammunition to restrict access". But in the Mizuho Securities conference call, participants agreed that a reasonable estimate of the direct hospital cost of treating a stroke is around $20,000 to $40,000, while the total lifetime costs are about $100,000 for an elderly patient, and up to $500,000 for a young patient. People with naturally-occurring mutations in the gene encoding PCSK9 have lower levels of LDL cholesterol, and are protected from heart disease, strongly suggesting that an antibody against the PCSK9 protein should have the same beneficial effects - a story that remains the poster-child for exploiting human genetics to understand the biology of common diseases (such as heart disease) in the same way it revolutionised the discovery of new treatments for rare diseases a decade earlier.
Some doctors are less impressed with the new study, which was funded by Amgen.
Dr Marc Sabatine, from Brigham and Women's Hospital in MA and lead researcher on the study, will present the findings today (17th March) at the American College of Cardiology's (ACC) 66th Annual Scientific Session in Washington.
Professor Naveed Sattar, an expert in metabolic medicine at the University of Glasgow, said: 'Can we realistically afford to extend the guidelines to bring these drugs to more people? If a patient has a heart attack or stroke while taking Repatha as prescribed, Amgen will refund the cost of treatment. However, it has been created to target a protein in the liver with the name PCSK9. Patients took either statins alone, or Repatha with their statins.
Given its price, doctors aren't likely to give Repatha to everyone with high cholesterol, Patterson said.
But they were approved only for those with a genetic condition that means they have dangerously high cholesterol, and people with heart disease who can not cope with the side effects of statins. The implication, he said, is that larger benefit is "probably a true reflection of what patients will experience if they take the drug over time".
Amgen believes it has the cardiovascular outcomes data it needs to inject some renewed momentum into its laggard cholesterol-lowering antibody Repatha, but reaction to the results has been muted.
While Amgen said in a statement that those differences weren't notable, Topol disagreed, and said that the increase in instances of diabetes partially offsets evolocumab's reduction in heart attacks. Pfizer, the drug's manufacturer, halted development of bococizumab in November.
Meanwhile, Kushner Companies has said that they are in "active discussion" around the property, but "nothing has been finalized". Kushner, who is husband to Trump's daughter Ivanka, has now surfaced as a de facto USA envoy under the current presidency.
No hazardous materials were found during a search of a backpack the individual carried over the fence, the agency said. John Kelly, head of the US Department of Homeland Security, was briefed on the security breach.
Pollsters have predicted the BJP as the party emerging with the largest votes in Uttar Pradesh, Uttarakhand, Goa and Manipur. Jaswantnagar, part of Mainpuri Lok Sabha seat, was represented by Mulayam who had won the seat first time in 1967.
Considering that Armitage would be headlining Young Sheldon , however, the adorable actor has some pretty big shoes to fill. When The Big Bang Theory started Sheldon was colder than ice and his personality wasn't "human" at all.
Already numerous political party leaders have cast their votes across the Netherlands in thee parliamentary election. His Freedom Party had been leading in opinion polls but they have since suggested his support may be slipping.
Jennifer Lopez flew to the Florida city on Friday, March 10, to spend time with her new boyfriend, Alex Rodriguez. Jennifer has since reportedly moved on from her Drake romance with former baseball player Alex Rodriguez .
Bogut was traded to Dallas to make salary cap room for the Warriors to obtain Kevin Durant, who is also sidelined with an injury. Coach Tyronn Lue didn't attend practice as he's being treated for a sinus/inner ear issue.
But the BJP faced criticism for choosing a leader who has propagated converting India, a multi-faith country, into a Hindu nation. Meanwhile, who would become the next chief minister of Uttar Pradesh is still not confirmed.
But Robart was unwilling to extend his initial ruling to over the second order, saying that a new motion would have to be filed. Washington state won an initial effort to block Trump's first travel ban and is asking a judge to block the revised ban.
Honda Cars India launches WR-V at Rs 7.75 lakh
The higher version of the petrol VX model is priced at Rs 8.99 lakh, and that of the diesel variant is priced at Rs 9.99 lakh. The WR-V will be available in petrol and diesel variants, and is the first in its class to get an electric sunroof.
Texans trying to trade for Patriots CB Malcolm Butler
After all, it was his interception on a shocking Russell Wilson pass attempt that sealed New England's victory in Super Bowl XLIX. The Patriots don't have a first, or second-round pick, so keep that in mind as the Patriots look to potentially trade Butler.
Turkey mulling over sanctions on the Netherlands
He added, "If tension will increase (between the two countries) because of my visit, then let it increase". Some local authorities in Germany, Austria and Switzerland have earlier called off Turkish rallies.
Iran Air receives 2nd of 100 Airbus jets
The Airbus A330 is a medium- to long-range wide-body twin-engine jet airliner made by Airbus, a division of Airbus Group. Iran Air is also expected to finalize an accord with European manufacturer ATR to purchase 20 turboprops.
Jennifer Lopez and Alex Rodriguez: It's on!
However, she does not feel like she only goes for younger dudes, she just dates the one she can have a connection with. Like Lopez, Rodriguez has previously been linked to a number of A-list celebrities, including Madonna and Kate Hudson.